A Novel Approach for Reducing Catheter Associated Urinary Tract Infections in Intermittent Catheter Users
Sarangapani Shantha, Hopke Katherine
Catheter-associated urinary tract infections (CAUTI) are a recurring problem for individuals with
neurogenic bladder who rely on frequent intermittent catheterization. Dysbiosis of the urine microbiome,
characterized by the presence of pathogenic organisms and insufficient levels of Lactobacilli, is common
in this population. We propose that introducing beneficial Lactobacilli via a catheter lubricant could act
as a prophylactic "live barrier" to enhance beneficial bacteria in the urethra.
The IC TF1 Catheter Lubricant gel discussed in this study is a freshly prepared viscous gel composed of
sterile gelling components and a dry Lactobacillus Rhamnosus spp. powder. The gel prepared on- site
by simple mixing, is usable for 24 hours with predictable and precise viability counts. Our investigation
focuses on the design, physical attributes, manufacturability with quality control criteria, stability of
probiotic viability, antimicrobial properties, cellular toxicity, and tissue compatibility of the IC TF1
gel. The gel demonstrates promising physical properties and biocompatibility, leading to the need
for further pre-clinical and human trials to assess its safety and effectiveness in reducing pathogenic
urethral colonization.
The localized delivery of probiotic supplementation through catheter lubrication has the potential to
enhance the well-being of individuals with neurogenic bladder and aid in the management of CAUTI.
