Case Reports and Reviews

Case Report - Basal Cell Carcinoma of Skin with Myoepithelial Differentiation (BCC-MED) : A Rare Diagnostic Entity

Naveen Naz,

Naveen Naz

Department of Pathology and Molecular Medicine, St Joseph’s Healthcare (HRLMP), McMaster University, Hamilton, ON, Canada.

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Josephine A D'Abbondanza,

Josephine A D'Abbondanza

Department of Surgery, Division of Plastic Surgery, St Joseph’s Healthcare, McMaster University, Hamilton, ON, Canada.

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Maya Suzette Anderson,

Maya Suzette Anderson

Department of Surgery, Division of Plastic Surgery, St Joseph’s Healthcare, McMaster University, Hamilton, ON, Canada.

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Altaf Taher,

Altaf Taher

Department of Pathology and Molecular Medicine, St Joseph’s Healthcare (HRLMP), McMaster University, Hamilton, ON, Canada.

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Samih S Salama

Samih S Salama

Department of Pathology and Molecular Medicine, St Joseph’s Healthcare (HRLMP), McMaster University, Hamilton, ON, Canada.

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  10.33425/2693-1516.1070
Basal cell carcinoma (BCC) with myoepithelial differentiation is a rare histopathologic variant that may pose significant diagnostic challenges because of its unusual cytomorphology and broad immunophenotype. We report the case of an 83-year-old man with multiple facial cutaneous malignancies, including the current unusual BCC of the left upper cheek showing prominent myoepithelial differentiation. The lesion was initially interpreted as a poorly differentiated malignant neoplasm with a broad differential diagnosis including melanoma and plasmacytoid squamous cell carcinoma. Subsequent histochemical and immunohistochemical studies supported the diagnosis of BCC with myoepithelial differentiation. We discuss the clinicopathologic features, immunophenotype, differential diagnosis, and current understanding of this rare entity in the context of the existing literature.
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