Exploring The Mechanism Of Action Of The Combination Of Oleanolic Acid And Aspirin In The Treatment Of Colorectal Cancer
Shengnan Lin, Ying Chen, Fang Huang, Mengya Lin, Luning Xu
Colorectal cancer (CRC) is one of the common malignancies, and the drug resistance and severe toxicity
generated by long-term chemotherapy in colorectal cancer patients severely limit the efficiency of
chemotherapy for colorectal cancer. Aspirin is currently one of the most promising chemopreventive
drugs for CRC, but its long-term use is prone to side effects such as gastrointestinal bleeding, which limits
its clinical application. Oleanolic acid is an effective anti-tumor drug, which can inhibit the proliferation
of many kinds of colorectal cancer cells in colorectal cancer. Therefore, this study was designed to
investigate the potential mechanism of action of the combination of oleanolic acid and aspirin against
colorectal cancer through in vitro experiments. The results of cellular assays showed that oleanolic acid
and aspirin inhibited the proliferation of HT-29 and HCT-116 cells, and oleanolic acid dose-dependently
inhibited the expression of PTGS2 in HT-29 cells and enhanced the expression of PTGS2 and inhibited
the degradation of IκBα in colorectal cancer cells by aspirin. This study reports for the first time the antinovel combination of oleanolic acid and aspirin against colorectal cancer. It provides a new direction for
the development of new drugs for the treatment of colorectal cancer.
