Mitochondrial Dysfunction in Osteosarcoma Patients
Daigo Hirao, Adil Maqbool, Takehito Sugasawa, AKM Shaharul Islam, Arifur Rahman, Farzana Sohael, Chishimba Nathan Mowa, Nobutake Shimojo, Subrina Jesmin
This review aims to explore the relationship between mitochondrial dysfunction and osteosarcoma
progression. Osteosarcoma, a highly malignant primary bone tumor, has long been linked to various
metabolic alterations, including mitochondrial anomalies. Mitochondria, known for their roles
in energy production, reactive oxygen species regulation, and apoptosis, are implicated in cancer
pathogenesis. This paper consolidates evidence from multiple studies, highlighting how mitochondrial
dysfunction contributes to osteosarcoma development, tumor growth, and metastasis. Findings suggest
that abnormal mitochondrial functions—ranging from disrupted energy metabolism to metabolic
reprogramming—significantly impact tumor progression. Despite these insights, challenges persist in
establishing a direct causal relationship. The review identifies potential therapeutic strategies targeting
mitochondrial pathways and emphasizes the need for further studies to clarify mechanisms linking
mitochondrial dysfunction and osteosarcoma.
