Subcutaneous Panniculitis in Sickle Cell Disease (SCD): A Rare Disease Complication
Sharena Scott, Christopher L. Edwards, Michaela Boggan, Jordan Meek, Mary Wood, W. Jeff Bryson, John J. Sollers, Camela S Barker, Gradi Sawuna-Luketo, McKenzie Broadnax, Noa Wax, Malik Muhammad, Jessica Miller, Brianna Downey, Elaine Whitworth, Roland Thorpe, Alexandria McDougald, Goldie Byrd, Keith Whitfield, Debra O Parker, Tanisha Burford, Jonathan Livingston, Elwood Robinson, Raymona Lawrence, Richard Boorst-Marx, Shiv Sudhakar, Ify Osunkwo
Objective: To delineate the explore potential etiological contributions to subcutaneous panniculitis-like
T-cell lymphoma (SPTCL) in adults with sickle cell disease. Sickle cell disease (SCD) is an inherited
hematologic disorder where standard treatment may enhance risk of the development of rare comorbidities like SPTCL.
Methods: We reviewed the scientific literature and only found one case report detailing the development
of SPTCL in an adult with SCD.
Results: We reviewed 1 case reports and the general literature on hematolymphoid disorders. We
discovered that there are several potential mechanisms to explain SPTCL in SCD but no conclusive
evidence to support either. We reported radiographic, serological, immune, and hematological finding
from the previous case.
Conclusions: SPTCL is a complex disorder with a likely multifactoral etiology. The development of the
disease in adults with SCD is rare but possible as evidenced by a published case report. We advocate
for additional attention to the intersection of these two diseases for the purpose of better understanding
their etiology and epidemiology. More research is needed.
