TY  - JOUR
AU  - Naveen Naz
AU  - Josephine A D'Abbondanza
AU  - Maya Suzette Anderson
AU  - Altaf Taher
AU  - Samih S Salama
PY  - 2026
DA  - 2026/01/04
TI  - Case Report - Basal Cell Carcinoma of Skin with Myoepithelial Differentiation (BCC-MED) : A Rare Diagnostic Entity
JO  - Case Reports and Reviews
VL  - 6
IS  - 1
AB  - Basal cell carcinoma (BCC) with myoepithelial differentiation is a rare histopathologic variant
that may pose significant diagnostic challenges because of its unusual cytomorphology and broad
immunophenotype.
We report the case of an 83-year-old man with multiple facial cutaneous malignancies, including the
current unusual BCC of the left upper cheek showing prominent myoepithelial differentiation. The
lesion was initially interpreted as a poorly differentiated malignant neoplasm with a broad differential
diagnosis including melanoma and plasmacytoid squamous cell carcinoma. Subsequent histochemical
and immunohistochemical studies supported the diagnosis of BCC with myoepithelial differentiation.
We discuss the clinicopathologic features, immunophenotype, differential diagnosis, and current
understanding of this rare entity in the context of the existing literature.
SN  - 2693-1516
UR  - https://dx.doi.org/10.33425/2693-1516.1070
DO  - 10.33425/2693-1516.1070