Evaluation, Prognosis and Risk factors in Hypertrophic Cardiomyopathy
Khaled Eid,
Ahmed Mosbah Taha Hassanein,
Abdulaziz Aboshahba,
Ahmed Hassan Elmedany,
Ahmed Galal A Fattah Fahmy
Introduction: Hypertrophic cardiomyopathy is a common genetic disease characterized by the presence
of abnormal wall thickness. Hyper-trophic cardiomyopathy can appear at any age, with the majority of
the patients remaining clinically stable. When patients complain of symptoms, these include: dyspnea,
syncope and angina. Hypertrophic cardiomyopathy is the most frequent cause of sudden cardiac death
in young adults and sports. Sudden cardiac death risk has been associated with different clinical risk
factors. However risk stratifications and prevention of sudden cardiac death are still challenges for the
clinicians.
Objectives: Our objectives are to evaluate the relation between traditional and novel risk factors and
SCD risk in our cohort of patients with HCM in order to improve the management of the disease.
Methods: In The institute of health sciences in the La coruña University we follow up more than 635
patients with HCM. The study will record the following risk factors for SCD A: Major risk factors:
1) Prior cardiac arrest or symptomatic sustained ventricular tachycardia. 2) Family history of a
premature sudden cardiac death. 3) Unexplained syncope. 4) Non-sustained ventricular tachycardia.
5) Abnormal blood pressure response during exercise. 6) Extreme left ventricular hypertrophy with
maximum wall thickness of 30 mm or more. B: Minor or possible risk factors: Atrial fibrillation ever,
Intense (competitive) physical exertion, Late gadolinium enhancement in magnetic resonance imaging.
The relation between the presence of these risks factors and development of SCD or appropriate
implantable cardioverter defibrillator discharge (AICD) will be evaluated by univariate and multivariate
survival analysis.
