TY  - JOUR
AU  - Ahaotu EO
AU  - Eliana Ibanez – Arancibia
AU  - Patricio De los Ríos
PY  - 2026
DA  - 2026/08/13
TI  - Ectoparasiticidal Activity of Neem (Azadirachta indica), Fish Poison (Tephrosia vogelii), Lemon Grass (Cymbopogon citratus) and Orange Peel (Citrus sinensis) against Mosquitoes, Ticks and Mites
JO  - Archives of Clinical Trials
VL  - 6
IS  - 2
AB  - Introduction: Inflammatory bowel disease (IBD) requires patient-centered care beyond pharmacological
therapy. DOCLIVI, a holistic digital assistant integrating nutrition, physical activity, and stress–emotion
regulation with personalized coaching, was developed to promote lifestyle modification in IBD. This
study evaluated its impact on quality of life and behavioral indicators of health.
Methods: This prospective, single-arm, multicenter study enrolled patients with Crohn’s disease or
ulcerative colitis on stable biologic therapy. Participants used the DOCLIVI app, which included three
programs (nutrition, physical activity/sedentary lifestyle, and stress–emotion regulation), and attended
three personalized video coaching sessions over six months. Outcomes included the IBD Disk (quality
of life and functional disability), PSS-10 (stress), and behavioral questionnaires assessing nutrition,
physical activity (RICCI & GAGNON), sedentary lifestyle, sleep, circadian rhythm, connection to
nature, and social-emotional well-being.
Results: Forty-one patients were included; 34 completed the program (mean age 35.5 years, 28 women).
IBD Disk scores improved significantly (55.8 → 37.1; mean difference = 18.7; p < 0.001; Cohen’s d =
1.01), with 40% achieving satisfactory quality of life (score < 40). Improvements were observed in 9 of
10 domains, including anxiety, fatigue and sleep. Healthy eating habits improved (+0.97; p = 0.010),
physical activity increased by 23.6% (p = 0.043), and contact with nature rose from 58.8% to 76.5% (p
= 0.014). Adherence and satisfaction were high, with 65% of participants achieving their goals.
Conclusion: Digital holistic care combining lifestyle modules and personalized coaching significantly
improved quality of life and lifestyle behaviors in IBD patients. Sustained engagement may enhance
long-term benefits.
SN  - 2768-4598
UR  - https://dx.doi.org/Not Assigned
DO  - Not Assigned